Interações medicamentosas
Clindamycin + Rapacuronium
Gravidade: Grave
Clindamycin and Rapacuronium: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Clindamycin has intrinsic neuromuscular blocking activity and can potentiate non-depolarizing neuromuscular blockers. This may prolong paralysis and cause delayed respiratory depression. Rapacuronium has been withdrawn from the market in most countries, so this is mainly of historical relevance.
O que esta interação significa em palavras simples
Clindamycin and Rapacuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Clindamycin has additive pre- and postsynaptic neuromuscular blocking effects that potentiate non-depolarizing blockade.
O que fazer
Avoid the combination where possible. If a neuromuscular blocker and clindamycin must be given together, use quantitative neuromuscular monitoring and have ventilatory support available until full recovery is confirmed.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Clindamycin
Perguntas frequentes
Can I take Clindamycin with Rapacuronium?
MediHelp rates the interaction as major. Clindamycin and Rapacuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clindamycin has intrinsic neuromuscular blocking activity and can potentiate non-depolarizing neuromuscular blockers. This may prolong paralysis and cause delayed respiratory depression. Rapacuronium has been withdrawn from the market in most countries, so this is mainly of historical relevance.
How serious is the interaction between Clindamycin and Rapacuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If a neuromuscular blocker and clindamycin must be given together, use quantitative neuromuscular monitoring and have ventilatory support available until full recovery is confirmed.
What other medicines interact with Clindamycin?
MediHelp also lists interactions of Clindamycin with, for example, Atracurium, Cisatracurium, Microbiota. The full list is on the Clindamycin page.
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