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Interações medicamentosas

Clindamycin + Vecuronium

Gravidade: Grave

Clindamycin and Vecuronium: major interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

O conteúdo clínico desta página está disponível apenas em inglês.

Resumo

Clindamycin has intrinsic neuromuscular blocking activity and can deepen and prolong paralysis from vecuronium. Recovery of spontaneous breathing may be delayed.

O que esta interação significa em palavras simples

Clindamycin and Vecuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Clindamycin belongs to Anti Bacterial; Vecuronium belongs to Musculoskeletal.

Nível de evidência: Moderate

Por que acontece

Additive neuromuscular blockade through presynaptic and postsynaptic inhibition of transmission by clindamycin.

O que fazer

Monitor train-of-four and titrate vecuronium to effect. Ensure full recovery of neuromuscular function before extubation.

O que perguntar ao farmacêutico

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Perguntas frequentes

Can I take Clindamycin with Vecuronium?

MediHelp rates the interaction as major. Clindamycin and Vecuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clindamycin has intrinsic neuromuscular blocking activity and can deepen and prolong paralysis from vecuronium. Recovery of spontaneous breathing may be delayed.

How serious is the interaction between Clindamycin and Vecuronium?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor train-of-four and titrate vecuronium to effect. Ensure full recovery of neuromuscular function before extubation.

What other medicines interact with Vecuronium?

MediHelp also lists interactions of Vecuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Vecuronium page.

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