Interações medicamentosas
Clopidogrel + Repaglinide
Gravidade: Grave
Clopidogrel and Repaglinide: major interaction.
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Resumo
Clopidogrel, through its acyl glucuronide metabolite, inhibits CYP2C8 and markedly raises repaglinide exposure. This increases the risk of prolonged or severe hypoglycemia.
O que esta interação significa em palavras simples
Clopidogrel and Repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clopidogrel belongs to Cardiovascular; Repaglinide belongs to Endocrine.
Por que acontece
Inhibition of CYP2C8-mediated repaglinide metabolism by clopidogrel's glucuronide metabolite.
O que fazer
Avoid the combination where possible and choose another antidiabetic agent. If it must be used, reduce the repaglinide dose to the lowest level, cap the daily dose per labeling, and monitor blood glucose closely.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Clopidogrel
Outras interações de Repaglinide
- Gemfibrozil + Repaglinide Contraindicada
- Clarithromycin + Repaglinide Grave
- Cobicistat + Repaglinide Grave
- Cyclosporine + Repaglinide Grave
- Cyclosporin + Repaglinide Grave
- Deferasirox + Repaglinide Grave
Perguntas frequentes
Can I take Clopidogrel with Repaglinide?
MediHelp rates the interaction as major. Clopidogrel and Repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clopidogrel, through its acyl glucuronide metabolite, inhibits CYP2C8 and markedly raises repaglinide exposure. This increases the risk of prolonged or severe hypoglycemia.
How serious is the interaction between Clopidogrel and Repaglinide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose another antidiabetic agent. If it must be used, reduce the repaglinide dose to the lowest level, cap the daily dose per labeling, and monitor blood glucose closely.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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