Interações medicamentosas
Clarithromycin + Repaglinide
Gravidade: Grave
Clarithromycin and Repaglinide: major interaction.
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Resumo
Clarithromycin increases repaglinide exposure, which can lead to prolonged or severe hypoglycemia. The interaction is clinically meaningful.
O que esta interação significa em palavras simples
Clarithromycin and Repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Repaglinide belongs to Endocrine.
Por que acontece
Clarithromycin inhibits CYP3A4 (and possibly OATP1B1), decreasing repaglinide clearance.
O que fazer
Monitor blood glucose closely and reduce the repaglinide dose if needed; prefer a non-interacting antibiotic. Warn patients about hypoglycemia symptoms.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Clarithromycin
- Astemizole + Clarithromycin Contraindicada
- Avanafil + Clarithromycin Contraindicada
- Cisapride + Clarithromycin Contraindicada
- Clarithromycin + Colchicine Contraindicada
- Clarithromycin + Conivaptan Contraindicada
- Clarithromycin + Dihydroergotamine Contraindicada
Outras interações de Repaglinide
- Gemfibrozil + Repaglinide Contraindicada
- Clopidogrel + Repaglinide Grave
- Cobicistat + Repaglinide Grave
- Cyclosporine + Repaglinide Grave
- Cyclosporin + Repaglinide Grave
- Deferasirox + Repaglinide Grave
Perguntas frequentes
Can I take Clarithromycin with Repaglinide?
MediHelp rates the interaction as major. Clarithromycin and Repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin increases repaglinide exposure, which can lead to prolonged or severe hypoglycemia. The interaction is clinically meaningful.
How serious is the interaction between Clarithromycin and Repaglinide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the repaglinide dose if needed; prefer a non-interacting antibiotic. Warn patients about hypoglycemia symptoms.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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