Interações medicamentosas
Cyclobenzaprine + Selegiline transdermal
Gravidade: Contraindicada
Cyclobenzaprine and Selegiline transdermal: contraindicated interaction.
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Resumo
Cyclobenzaprine is structurally related to tricyclic antidepressants, and its labeling contraindicates use with or within 14 days of MAO inhibitors. Combining it with selegiline, an MAO inhibitor, can cause serotonin syndrome, hypertensive crisis, severe convulsions, and death.
O que esta interação significa em palavras simples
Cyclobenzaprine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Inhibition of MAO by selegiline combined with the serotonergic and noradrenergic reuptake effects of cyclobenzaprine leads to excess monoamine activity.
O que fazer
Avoid the combination and choose a non-serotonergic muscle relaxant. Allow a washout of at least 14 days after stopping an MAO inhibitor before starting cyclobenzaprine.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicada
- Cyclobenzaprine + Linezolid Contraindicada
- Cyclobenzaprine + Phenelzine Contraindicada
- Cyclobenzaprine + Safinamide Contraindicada
- Cyclobenzaprine + Selegiline Contraindicada
- Cyclobenzaprine + Tranylcypromine Contraindicada
Perguntas frequentes
Can I take Cyclobenzaprine with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Cyclobenzaprine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cyclobenzaprine is structurally related to tricyclic antidepressants, and its labeling contraindicates use with or within 14 days of MAO inhibitors. Combining it with selegiline, an MAO inhibitor, can cause serotonin syndrome, hypertensive crisis, severe convulsions, and death.
How serious is the interaction between Cyclobenzaprine and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-serotonergic muscle relaxant. Allow a washout of at least 14 days after stopping an MAO inhibitor before starting cyclobenzaprine.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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