Interações medicamentosas
Cyclobenzaprine + Tranylcypromine
Gravidade: Contraindicada
Cyclobenzaprine and Tranylcypromine: contraindicated interaction.
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Resumo
Tranylcypromine inhibits monoamine oxidase and so reduces serotonin breakdown, while cyclobenzaprine is a tricyclic-related muscle relaxant that inhibits serotonin and norepinephrine reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal. Hypertensive reactions are also possible with tricyclic agents.
O que esta interação significa em palavras simples
Cyclobenzaprine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cyclobenzaprine belongs to Musculoskeletal; Tranylcypromine belongs to Central Nervous System.
Por que acontece
Additive serotonergic activity: irreversible non-selective MAO inhibition plus monoamine reuptake inhibition
O que fazer
Do not combine; allow at least 14 days after stopping the tranylcypromine before starting cyclobenzaprine, and at least 14 days after stopping cyclobenzaprine before starting the tranylcypromine.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicada
- Cyclobenzaprine + Linezolid Contraindicada
- Cyclobenzaprine + Phenelzine Contraindicada
- Cyclobenzaprine + Safinamide Contraindicada
- Cyclobenzaprine + Selegiline Contraindicada
- Cyclobenzaprine + Selegiline transdermal Contraindicada
Outras interações de Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicada
- Amitriptyline + Tranylcypromine Contraindicada
- Amoxapine + Tranylcypromine Contraindicada
- Atomoxetine + Tranylcypromine Contraindicada
- Benzphetamine + Tranylcypromine Contraindicada
- Brimonidine + Tranylcypromine Contraindicada
Perguntas frequentes
Can I take Cyclobenzaprine with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Cyclobenzaprine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tranylcypromine inhibits monoamine oxidase and so reduces serotonin breakdown, while cyclobenzaprine is a tricyclic-related muscle relaxant that inhibits serotonin and norepinephrine reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal. Hypertensive reactions are also possible with tricyclic agents.
How serious is the interaction between Cyclobenzaprine and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow at least 14 days after stopping the tranylcypromine before starting cyclobenzaprine, and at least 14 days after stopping cyclobenzaprine before starting the tranylcypromine.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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