Interações medicamentosas
Cyclosporin + Dengue vaccine
Gravidade: Contraindicada
Cyclosporin and Dengue vaccine: contraindicated interaction.
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Resumo
The dengue vaccine is a live attenuated vaccine, so in a patient on cyclosporin the vaccine virus may replicate excessively and cause disease. The immune response may also be inadequate.
O que esta interação significa em palavras simples
Cyclosporin and Dengue vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Impaired cell-mediated immunity from calcineurin inhibition allows uncontrolled replication of the live vaccine virus and weakens the response.
O que fazer
Do not administer the dengue vaccine during cyclosporin therapy. Consider vaccination only after immunosuppression has been stopped for an adequate interval, in consultation with a specialist.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicada
- Aliskiren + Cyclosporin Contraindicada
- Bcg vaccine live + Cyclosporin Contraindicada
- Bosentan + Cyclosporin Contraindicada
- Cidofovir + Cyclosporin Contraindicada
- Cyclosporin + Elagolix Contraindicada
Perguntas frequentes
Can I take Cyclosporin with Dengue vaccine?
MediHelp rates the interaction as contraindicated. Cyclosporin and Dengue vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The dengue vaccine is a live attenuated vaccine, so in a patient on cyclosporin the vaccine virus may replicate excessively and cause disease. The immune response may also be inadequate.
How serious is the interaction between Cyclosporin and Dengue vaccine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not administer the dengue vaccine during cyclosporin therapy. Consider vaccination only after immunosuppression has been stopped for an adequate interval, in consultation with a specialist.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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