Interações medicamentosas
Cyclosporine + Doxorubicin
Gravidade: Grave
Cyclosporine and Doxorubicin: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Cyclosporine inhibits P-gp and CYP3A4 and can raise doxorubicin exposure, with increased myelosuppression, mucositis and cardiotoxicity. Prolonged neutropenia and severe toxicity have been reported with the combination.
O que esta interação significa em palavras simples
Cyclosporine and Doxorubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Cyclosporine inhibits P-glycoprotein and CYP3A4, reducing doxorubicin clearance.
O que fazer
Avoid if possible; if combined, consider reducing the doxorubicin dose and monitor blood counts and cardiac function closely.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Cyclosporine e Doxorubicin, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Doxorubicin
Perguntas frequentes
Can I take Cyclosporine with Doxorubicin?
MediHelp rates the interaction as major. Cyclosporine and Doxorubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine inhibits P-gp and CYP3A4 and can raise doxorubicin exposure, with increased myelosuppression, mucositis and cardiotoxicity. Prolonged neutropenia and severe toxicity have been reported with the combination.
How serious is the interaction between Cyclosporine and Doxorubicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if combined, consider reducing the doxorubicin dose and monitor blood counts and cardiac function closely.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
