Interações medicamentosas
Cyclophosphamide + Doxorubicin
Gravidade: Grave
Cyclophosphamide and Doxorubicin: major interaction.
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Resumo
Both drugs are cardiotoxic, and combining them increases the risk of cardiac injury, particularly with high-dose cyclophosphamide and higher cumulative anthracycline doses. Additive myelosuppression also occurs, and cyclophosphamide's own urotoxicity remains a concern.
O que esta interação significa em palavras simples
Cyclophosphamide and Doxorubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclophosphamide belongs to Oncology; Doxorubicin belongs to Oncology.
Por que acontece
Additive cardiotoxic and myelosuppressive effects, with possible enhanced cyclophosphamide toxicity that is not fully characterized.
O que fazer
Monitor cardiac function (LVEF) and limit cumulative doxorubicin exposure, and follow blood counts. Ensure adequate hydration and mesna where indicated to protect the bladder.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Cyclophosphamide
Outras interações de Doxorubicin
Perguntas frequentes
Can I take Cyclophosphamide with Doxorubicin?
MediHelp rates the interaction as major. Cyclophosphamide and Doxorubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are cardiotoxic, and combining them increases the risk of cardiac injury, particularly with high-dose cyclophosphamide and higher cumulative anthracycline doses. Additive myelosuppression also occurs, and cyclophosphamide's own urotoxicity remains a concern.
How serious is the interaction between Cyclophosphamide and Doxorubicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cardiac function (LVEF) and limit cumulative doxorubicin exposure, and follow blood counts. Ensure adequate hydration and mesna where indicated to protect the bladder.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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