Interações medicamentosas
Cyclosporine + Rifaximin
Gravidade: Moderada
Cyclosporine and Rifaximin: moderate interaction.
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Resumo
Cyclosporine strongly inhibits P-glycoprotein and caused very large increases in rifaximin systemic exposure in healthy volunteers. This could matter in patients with impaired gut barrier or liver disease, where rifaximin exposure is already higher.
O que esta interação significa em palavras simples
Cyclosporine and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Cyclosporine inhibition of P-glycoprotein markedly increases rifaximin absorption.
O que fazer
Use together only if the benefit justifies it and monitor for rifaximin adverse effects. Avoid or reassess in patients with severe hepatic impairment.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Rifaximin
- Cholera vaccine + Rifaximin Grave
- Microbiota + Rifaximin Grave
- Amiodarone + Rifaximin Moderada
- Bcg intravesical live + Rifaximin Moderada
- Cyclosporin + Rifaximin Moderada
- Dronedarone + Rifaximin Moderada
Perguntas frequentes
Can I take Cyclosporine with Rifaximin?
MediHelp rates the interaction as moderate. Cyclosporine and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine strongly inhibits P-glycoprotein and caused very large increases in rifaximin systemic exposure in healthy volunteers. This could matter in patients with impaired gut barrier or liver disease, where rifaximin exposure is already higher.
How serious is the interaction between Cyclosporine and Rifaximin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only if the benefit justifies it and monitor for rifaximin adverse effects. Avoid or reassess in patients with severe hepatic impairment.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Amiodarone. The full list is on the Rifaximin page.
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