Interações medicamentosas
Cyclosporin + Rifaximin
Gravidade: Moderada
Cyclosporin and Rifaximin: moderate interaction.
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Resumo
Cyclosporine markedly increases systemic absorption of rifaximin, which is normally minimally absorbed. In patients with intact gut barrier this has been very large, and the consequences of such exposure are not well defined.
O que esta interação significa em palavras simples
Cyclosporin and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Rifaximin belongs to Anti Bacterial.
Por que acontece
Cyclosporine inhibits P-glycoprotein, which limits rifaximin absorption, greatly increasing systemic rifaximin levels.
O que fazer
Avoid combining where possible, particularly in patients with severe hepatic impairment. If used, monitor for adverse effects of rifaximin and for changes in cyclosporine levels.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicada
- Aliskiren + Cyclosporin Contraindicada
- Bcg vaccine live + Cyclosporin Contraindicada
- Bosentan + Cyclosporin Contraindicada
- Cidofovir + Cyclosporin Contraindicada
- Cyclosporin + Dengue vaccine Contraindicada
Outras interações de Rifaximin
- Cholera vaccine + Rifaximin Grave
- Microbiota + Rifaximin Grave
- Amiodarone + Rifaximin Moderada
- Bcg intravesical live + Rifaximin Moderada
- Cyclosporine + Rifaximin Moderada
- Dronedarone + Rifaximin Moderada
Perguntas frequentes
Can I take Cyclosporin with Rifaximin?
MediHelp rates the interaction as moderate. Cyclosporin and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine markedly increases systemic absorption of rifaximin, which is normally minimally absorbed. In patients with intact gut barrier this has been very large, and the consequences of such exposure are not well defined.
How serious is the interaction between Cyclosporin and Rifaximin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, particularly in patients with severe hepatic impairment. If used, monitor for adverse effects of rifaximin and for changes in cyclosporine levels.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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