Interações medicamentosas
Dantrolene + Dextromoramide
Gravidade: Grave
Dantrolene and Dextromoramide: major interaction.
Última atualização Fontes: UK SmPC
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Dextromoramide is a potent opioid analgesic that causes sedation and respiratory depression, and dantrolene adds drowsiness and muscle weakness. Together they may increase the risk of excessive sedation and impaired breathing, particularly in frail patients or at higher doses.
O que esta interação significa em palavras simples
Dantrolene and Dextromoramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive CNS depression from opioid action combined with dantrolene sedation and muscle weakness.
O que fazer
Start with the lowest effective opioid dose and titrate slowly while monitoring sedation and respiratory rate. Counsel patients to avoid driving and other CNS depressants.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Dantrolene
Perguntas frequentes
Can I take Dantrolene with Dextromoramide?
MediHelp rates the interaction as major. Dantrolene and Dextromoramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dextromoramide is a potent opioid analgesic that causes sedation and respiratory depression, and dantrolene adds drowsiness and muscle weakness. Together they may increase the risk of excessive sedation and impaired breathing, particularly in frail patients or at higher doses.
How serious is the interaction between Dantrolene and Dextromoramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective opioid dose and titrate slowly while monitoring sedation and respiratory rate. Counsel patients to avoid driving and other CNS depressants.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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