Interações medicamentosas
Buprenorphine long-acting + Dantrolene
Gravidade: Grave
Buprenorphine long-acting and Dantrolene: major interaction.
Última atualização Fontes: UK SmPC
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Dantrolene causes drowsiness and muscle weakness, and long-acting injectable buprenorphine adds sustained opioid sedation and respiratory depression. Because the injection cannot be withdrawn, the effect can last a long time.
O que esta interação significa em palavras simples
Buprenorphine long-acting and Dantrolene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive central nervous system and respiratory depression from buprenorphine with dantrolene's sedation and muscle weakness.
O que fazer
Use together only when alternatives are inadequate, and monitor for sedation and respiratory depression. Reduce dantrolene dose if excessive drowsiness occurs.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Dantrolene
Perguntas frequentes
Can I take Buprenorphine long-acting with Dantrolene?
MediHelp rates the interaction as major. Buprenorphine long-acting and Dantrolene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dantrolene causes drowsiness and muscle weakness, and long-acting injectable buprenorphine adds sustained opioid sedation and respiratory depression. Because the injection cannot be withdrawn, the effect can last a long time.
How serious is the interaction between Buprenorphine long-acting and Dantrolene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only when alternatives are inadequate, and monitor for sedation and respiratory depression. Reduce dantrolene dose if excessive drowsiness occurs.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine subdermal implant, Buprenorphine transdermal. The full list is on the Dantrolene page.
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