Interações medicamentosas
Dapagliflozin-metformin + Diatrizoate meglumine / diatrizoate
Gravidade: Grave
Dapagliflozin-metformin and Diatrizoate meglumine / diatrizoate: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Intravascular iodinated contrast can cause acute kidney injury, and metformin accumulation in that setting raises the risk of lactic acidosis. This is rare but potentially serious, particularly in patients with impaired renal function.
O que esta interação significa em palavras simples
Dapagliflozin-metformin and Diatrizoate meglumine / diatrizoate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Contrast-induced decline in renal function reduces metformin elimination, leading to accumulation and lactic acidosis.
O que fazer
Hold metformin at the time of or before the procedure in patients with eGFR below 30, in acute kidney injury, or with intra-arterial contrast. Re-check renal function about 48 hours afterward and restart metformin only if it is stable.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Dapagliflozin-metformin
Perguntas frequentes
Can I take Dapagliflozin-metformin with Diatrizoate meglumine / diatrizoate?
MediHelp rates the interaction as major. Dapagliflozin-metformin and Diatrizoate meglumine / diatrizoate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Intravascular iodinated contrast can cause acute kidney injury, and metformin accumulation in that setting raises the risk of lactic acidosis. This is rare but potentially serious, particularly in patients with impaired renal function.
How serious is the interaction between Dapagliflozin-metformin and Diatrizoate meglumine / diatrizoate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold metformin at the time of or before the procedure in patients with eGFR below 30, in acute kidney injury, or with intra-arterial contrast. Re-check renal function about 48 hours afterward and restart metformin only if it is stable.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Ethanol. The full list is on the Dapagliflozin-metformin page.
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