Interações medicamentosas
Daprodustat + Hydrochlorothiazide-irbesartan
Gravidade: Moderada
Daprodustat and Hydrochlorothiazide-irbesartan: moderate interaction.
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Resumo
Irbesartan is reported to be a CYP2C8 inhibitor, and daprodustat is cleared mainly by CYP2C8. Exposure to daprodustat may therefore rise, increasing the risk of excessive erythropoietic response and related cardiovascular or thrombotic events.
O que esta interação significa em palavras simples
Daprodustat and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daprodustat belongs to Endocrine; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Por que acontece
Inhibition of CYP2C8-mediated metabolism of daprodustat raises its plasma concentrations.
O que fazer
Monitor hemoglobin closely when irbesartan is started or stopped and adjust the daprodustat dose accordingly. Consider a lower daprodustat starting dose if the combination is initiated together.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicada
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicada
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicada
- Aldesleukin + Hydrochlorothiazide-irbesartan Grave
- Amifostine + Hydrochlorothiazide-irbesartan Grave
- Amiloride + Hydrochlorothiazide-irbesartan Grave
Outras interações de Daprodustat
- Daprodustat + Gemfibrozil Contraindicada
- Abiraterone + Daprodustat Moderada
- Alogliptin-pioglitazone + Daprodustat Moderada
- Carbamazepine + Daprodustat Moderada
- Clopidogrel + Daprodustat Moderada
- Daprodustat + Deferasirox Moderada
Perguntas frequentes
Can I take Daprodustat with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Daprodustat and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Irbesartan is reported to be a CYP2C8 inhibitor, and daprodustat is cleared mainly by CYP2C8. Exposure to daprodustat may therefore rise, increasing the risk of excessive erythropoietic response and related cardiovascular or thrombotic events.
How serious is the interaction between Daprodustat and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin closely when irbesartan is started or stopped and adjust the daprodustat dose accordingly. Consider a lower daprodustat starting dose if the combination is initiated together.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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