Interações medicamentosas
Demeclocycline + Magnesium citrate
Gravidade: Moderada
Demeclocycline and Magnesium citrate: moderate interaction.
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Resumo
Magnesium forms insoluble chelates with tetracyclines such as demeclocycline in the gut, markedly reducing absorption. The laxative effect may also speed transit and further lower absorption, risking treatment failure.
O que esta interação significa em palavras simples
Demeclocycline and Magnesium citrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Chelation of demeclocycline by magnesium in the gastrointestinal tract reduces absorption.
O que fazer
Separate doses so demeclocycline is taken at least 2 hours before or 4 hours after magnesium citrate. Consider a different laxative if possible.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Magnesium citrate
- Ciprofloxacin + Magnesium citrate Grave
- Baloxavir marboxil + Magnesium citrate Moderada
- Bictegravir + Magnesium citrate Moderada
- Cabotegravir + Magnesium citrate Moderada
- Cholecalciferol + Magnesium citrate Moderada
- Deferiprone + Magnesium citrate Moderada
Perguntas frequentes
Can I take Demeclocycline with Magnesium citrate?
MediHelp rates the interaction as moderate. Demeclocycline and Magnesium citrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium forms insoluble chelates with tetracyclines such as demeclocycline in the gut, markedly reducing absorption. The laxative effect may also speed transit and further lower absorption, risking treatment failure.
How serious is the interaction between Demeclocycline and Magnesium citrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses so demeclocycline is taken at least 2 hours before or 4 hours after magnesium citrate. Consider a different laxative if possible.
What other medicines interact with Magnesium citrate?
MediHelp also lists interactions of Magnesium citrate with, for example, Ciprofloxacin, Baloxavir marboxil, Bictegravir. The full list is on the Magnesium citrate page.
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