Interações medicamentosas
Desogestrel-ethinyl estradiol + Elagolix
Gravidade: Grave
Desogestrel-ethinyl estradiol and Elagolix: major interaction.
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Resumo
Elagolix lowers estrogen levels, while estrogen-containing contraceptives are expected to oppose this effect and reduce its efficacy. Elagolix is also not a reliable contraceptive and may reduce hormonal contraceptive exposure.
O que esta interação significa em palavras simples
Desogestrel-ethinyl estradiol and Elagolix can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Desogestrel-ethinyl estradiol belongs to Endocrine; Elagolix belongs to Musculoskeletal.
Por que acontece
Pharmacodynamic antagonism between exogenous estrogen and elagolix-induced estrogen suppression.
O que fazer
Avoid estrogen-containing contraceptives and use non-hormonal contraception during elagolix therapy and for 1 week after stopping.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicada
- Aminocaproic acid + Desogestrel-ethinyl estradiol Grave
- Amobarbital + Desogestrel-ethinyl estradiol Grave
- Anastrozole + Desogestrel-ethinyl estradiol Grave
- Apalutamide + Desogestrel-ethinyl estradiol Grave
- Atazanavir + Desogestrel-ethinyl estradiol Grave
Outras interações de Elagolix
- Cyclosporin + Elagolix Contraindicada
- Elagolix + Gemfibrozil Contraindicada
- Elagolix + Erythromycin Grave
- Elagolix + Ethinyl estradiol-drospirenone Grave
- Elagolix + Ethinyl estradiol-levonorgestrel Grave
- Elagolix + Ketoconazole Grave
Perguntas frequentes
Can I take Desogestrel-ethinyl estradiol with Elagolix?
MediHelp rates the interaction as major. Desogestrel-ethinyl estradiol and Elagolix can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Elagolix lowers estrogen levels, while estrogen-containing contraceptives are expected to oppose this effect and reduce its efficacy. Elagolix is also not a reliable contraceptive and may reduce hormonal contraceptive exposure.
How serious is the interaction between Desogestrel-ethinyl estradiol and Elagolix?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid estrogen-containing contraceptives and use non-hormonal contraception during elagolix therapy and for 1 week after stopping.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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