Interações medicamentosas
Dienogest / estradiol valerate + Efavirenz
Gravidade: Contraindicada
Dienogest / estradiol valerate and Efavirenz: contraindicated interaction.
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Resumo
Efavirenz induces CYP3A4 and may lower dienogest and estradiol concentrations. This can reduce contraceptive efficacy and risk unintended pregnancy, and the inducing effect persists after efavirenz is stopped.
O que esta interação significa em palavras simples
Dienogest / estradiol valerate and Efavirenz are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Induction of CYP3A4 metabolism of dienogest and estradiol by efavirenz.
O que fazer
Do not rely on this product for contraception during efavirenz therapy; use an alternative method such as an intrauterine device. Continue the alternative method for several weeks after stopping efavirenz.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Efavirenz
- Cobimetinib + Efavirenz Contraindicada
- Dihydroergotamine intranasal + Efavirenz Contraindicada
- Dihydroergotamine + Efavirenz Contraindicada
- Doravirine + Efavirenz Contraindicada
- Efavirenz + Elbasvir / grazoprevir Contraindicada
- Efavirenz + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicada
Perguntas frequentes
Can I take Dienogest / estradiol valerate with Efavirenz?
MediHelp rates the interaction as contraindicated. Dienogest / estradiol valerate and Efavirenz are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Efavirenz induces CYP3A4 and may lower dienogest and estradiol concentrations. This can reduce contraceptive efficacy and risk unintended pregnancy, and the inducing effect persists after efavirenz is stopped.
How serious is the interaction between Dienogest / estradiol valerate and Efavirenz?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not rely on this product for contraception during efavirenz therapy; use an alternative method such as an intrauterine device. Continue the alternative method for several weeks after stopping efavirenz.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Efavirenz page.
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