Interações medicamentosas
Dihydroergotamine + Efavirenz
Gravidade: Contraindicada
Dihydroergotamine and Efavirenz: contraindicated interaction.
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Resumo
Efavirenz alters CYP3A4 activity and may change dihydroergotamine exposure unpredictably. Elevated ergot levels risk severe peripheral and cerebral ischemia, so the combination is avoided.
O que esta interação significa em palavras simples
Dihydroergotamine and Efavirenz are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dihydroergotamine belongs to Central Nervous System; Efavirenz belongs to Anti Virals.
Por que acontece
Efavirenz modulation of CYP3A4 metabolism of dihydroergotamine.
O que fazer
Avoid and treat migraine with a non-ergot alternative such as a triptan, taking its interactions into account.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Efavirenz
- Cobimetinib + Efavirenz Contraindicada
- Dienogest / estradiol valerate + Efavirenz Contraindicada
- Dihydroergotamine intranasal + Efavirenz Contraindicada
- Doravirine + Efavirenz Contraindicada
- Efavirenz + Elbasvir / grazoprevir Contraindicada
- Efavirenz + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicada
Outras interações de Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicada
- Clarithromycin + Dihydroergotamine Contraindicada
- Dihydroergotamine + Dopamine Contraindicada
- Dihydroergotamine + Dronedarone Contraindicada
- Dihydroergotamine + Eletriptan Contraindicada
- Dihydroergotamine + Ergotamine Contraindicada
Perguntas frequentes
Can I take Dihydroergotamine with Efavirenz?
MediHelp rates the interaction as contraindicated. Dihydroergotamine and Efavirenz are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Efavirenz alters CYP3A4 activity and may change dihydroergotamine exposure unpredictably. Elevated ergot levels risk severe peripheral and cerebral ischemia, so the combination is avoided.
How serious is the interaction between Dihydroergotamine and Efavirenz?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid and treat migraine with a non-ergot alternative such as a triptan, taking its interactions into account.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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