Interações medicamentosas
Dihydroergotamine intranasal + Voriconazole
Gravidade: Contraindicada
Dihydroergotamine intranasal and Voriconazole: contraindicated interaction.
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Resumo
Voriconazole raises systemic dihydroergotamine exposure from the nasal route and risks ergotism with severe vasospasm and ischemia.
O que esta interação significa em palavras simples
Dihydroergotamine intranasal and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Strong CYP3A4 inhibition by voriconazole reduces dihydroergotamine clearance.
O que fazer
Do not use together; use a non-ergot acute migraine treatment such as a triptan not affected by CYP3A4 inhibition.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Voriconazole
- Avanafil + Voriconazole Contraindicada
- Butabarbital + Voriconazole Contraindicada
- Carbamazepine + Voriconazole Contraindicada
- Conivaptan + Voriconazole Contraindicada
- Dihydroergotamine + Voriconazole Contraindicada
- Dofetilide + Voriconazole Contraindicada
Perguntas frequentes
Can I take Dihydroergotamine intranasal with Voriconazole?
MediHelp rates the interaction as contraindicated. Dihydroergotamine intranasal and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Voriconazole raises systemic dihydroergotamine exposure from the nasal route and risks ergotism with severe vasospasm and ischemia.
How serious is the interaction between Dihydroergotamine intranasal and Voriconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; use a non-ergot acute migraine treatment such as a triptan not affected by CYP3A4 inhibition.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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