Interações medicamentosas
Econazole + Warfarin
Gravidade: Moderada
Econazole and Warfarin: moderate interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Topical econazole applied over large areas, to genital skin or under occlusive dressings can be absorbed enough to raise the INR in patients taking warfarin. Bleeding episodes have been reported with azole antifungals used this way.
O que esta interação significa em palavras simples
Econazole and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Econazole belongs to Anti Fungals; Warfarin belongs to Cardiovascular.
Por que acontece
Systemically absorbed econazole inhibits CYP2C9 and other CYP enzymes, reducing clearance of the more potent S-warfarin.
O que fazer
Check INR within several days of starting econazole, particularly with extensive, genital or occluded application, and adjust the warfarin dose as needed. Limit the treated area where possible.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Warfarin
- Defibrotide + Warfarin Contraindicada
- Ketorolac + Warfarin Contraindicada
- Abciximab + Warfarin Grave
- Acetylsalicylic acid + Warfarin Grave
- Adagrasib + Warfarin Grave
- Amiodarone + Warfarin Grave
Perguntas frequentes
Can I take Econazole with Warfarin?
MediHelp rates the interaction as moderate. Econazole and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Topical econazole applied over large areas, to genital skin or under occlusive dressings can be absorbed enough to raise the INR in patients taking warfarin. Bleeding episodes have been reported with azole antifungals used this way.
How serious is the interaction between Econazole and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR within several days of starting econazole, particularly with extensive, genital or occluded application, and adjust the warfarin dose as needed. Limit the treated area where possible.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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