Interações medicamentosas
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lamivudine
Gravidade: Contraindicada
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Lamivudine: contraindicated interaction.
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Resumo
This fixed-dose product already contains emtricitabine, which is closely related to lamivudine, so adding lamivudine duplicates the same cytosine analogue activity. This provides no added benefit, gives overlapping resistance selection, and raises the toxicity burden.
O que esta interação significa em palavras simples
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Lamivudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Therapeutic duplication: lamivudine and emtricitabine are both cytidine analogues sharing the same target and resistance pathway.
O que fazer
Do not combine; the single-tablet regimen is complete and should not be given with other antiretrovirals. Stop lamivudine if the regimen is used.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Lamivudine
Perguntas frequentes
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Lamivudine?
MediHelp rates the interaction as contraindicated. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Lamivudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. This fixed-dose product already contains emtricitabine, which is closely related to lamivudine, so adding lamivudine duplicates the same cytosine analogue activity. This provides no added benefit, gives overlapping resistance selection, and raises the toxicity burden.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Lamivudine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; the single-tablet regimen is complete and should not be given with other antiretrovirals. Stop lamivudine if the regimen is used.
What other medicines interact with Lamivudine?
MediHelp also lists interactions of Lamivudine with, for example, Atidarsagene autotemcel, Betibeglogene autotemcel, Elivaldogene autotemcel. The full list is on the Lamivudine page.
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