Interações medicamentosas
Atidarsagene autotemcel + Lamivudine
Gravidade: Grave
Atidarsagene autotemcel and Lamivudine: major interaction.
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Resumo
Antiretrovirals such as lamivudine can interfere with manufacture of the gene-modified cell product because they inhibit the lentiviral vector transduction process. Patients taking them around the time of cell collection may produce an inadequate or unusable product.
O que esta interação significa em palavras simples
Atidarsagene autotemcel and Lamivudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atidarsagene autotemcel belongs to Miscellaneous; Lamivudine belongs to Anti Virals.
Por que acontece
Nucleoside reverse transcriptase inhibitors block reverse transcription of the lentiviral vector, impairing transduction of harvested cells.
O que fazer
Stop lamivudine at least one month before cell mobilization, or longer for drug elimination, and keep it off until apheresis is complete. Consult an HIV specialist for an alternative plan.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Lamivudine
Outras interações de Atidarsagene autotemcel
Perguntas frequentes
Can I take Atidarsagene autotemcel with Lamivudine?
MediHelp rates the interaction as major. Atidarsagene autotemcel and Lamivudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antiretrovirals such as lamivudine can interfere with manufacture of the gene-modified cell product because they inhibit the lentiviral vector transduction process. Patients taking them around the time of cell collection may produce an inadequate or unusable product.
How serious is the interaction between Atidarsagene autotemcel and Lamivudine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop lamivudine at least one month before cell mobilization, or longer for drug elimination, and keep it off until apheresis is complete. Consult an HIV specialist for an alternative plan.
What other medicines interact with Lamivudine?
MediHelp also lists interactions of Lamivudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Betibeglogene autotemcel, Elivaldogene autotemcel. The full list is on the Lamivudine page.
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