Interações medicamentosas
Erlotinib + Fosphenytoin
Gravidade: Grave
Erlotinib and Fosphenytoin: major interaction.
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Resumo
Fosphenytoin is converted to phenytoin, a strong CYP3A4 inducer, and may markedly lower erlotinib exposure. This can compromise cancer treatment.
O que esta interação significa em palavras simples
Erlotinib and Fosphenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erlotinib belongs to Oncology; Fosphenytoin belongs to Central Nervous System.
Por que acontece
Phenytoin induces CYP3A4 and possibly P-glycoprotein, increasing erlotinib clearance.
O que fazer
Use a non-inducing anticonvulsant where possible. If unavoidable, monitor response and consider increasing erlotinib dose as per labeling, with dose reduction after the inducer is stopped.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Erlotinib
- Amobarbital + Erlotinib Grave
- Apalutamide + Erlotinib Grave
- Carbamazepine + Erlotinib Grave
- Cobicistat + Erlotinib Grave
- Darunavir + Erlotinib Grave
- Dexlansoprazole + Erlotinib Grave
Outras interações de Fosphenytoin
- Dronedarone + Fosphenytoin Contraindicada
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicada
- Fosphenytoin + Lorlatinib Contraindicada
- Fosphenytoin + Lurasidone Contraindicada
- Fosphenytoin + Ranolazine Contraindicada
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicada
Perguntas frequentes
Can I take Erlotinib with Fosphenytoin?
MediHelp rates the interaction as major. Erlotinib and Fosphenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fosphenytoin is converted to phenytoin, a strong CYP3A4 inducer, and may markedly lower erlotinib exposure. This can compromise cancer treatment.
How serious is the interaction between Erlotinib and Fosphenytoin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inducing anticonvulsant where possible. If unavoidable, monitor response and consider increasing erlotinib dose as per labeling, with dose reduction after the inducer is stopped.
What other medicines interact with Erlotinib?
MediHelp also lists interactions of Erlotinib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Erlotinib page.
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