Interações medicamentosas
Dexlansoprazole + Erlotinib
Gravidade: Grave
Dexlansoprazole and Erlotinib: major interaction.
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Resumo
Dexlansoprazole raises gastric pH, which lowers the solubility and absorption of erlotinib. Reduced exposure may impair antitumour efficacy.
O que esta interação significa em palavras simples
Dexlansoprazole and Erlotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexlansoprazole belongs to Gastrointestinal Tract; Erlotinib belongs to Oncology.
Por que acontece
Gastric acid suppression reduces erlotinib dissolution and absorption
O que fazer
Avoid proton pump inhibitors if possible; if acid suppression is needed, use an H2 antagonist separated from erlotinib (erlotinib 2 hours before or 10 hours after) or an antacid separated by hours.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicada
- Dexlansoprazole + Rilpivirine Contraindicada
- Acalabrutinib + Dexlansoprazole Grave
- Atazanavir + Dexlansoprazole Grave
- Dacomitinib + Dexlansoprazole Grave
- Dasatinib + Dexlansoprazole Grave
Outras interações de Erlotinib
- Amobarbital + Erlotinib Grave
- Apalutamide + Erlotinib Grave
- Carbamazepine + Erlotinib Grave
- Cobicistat + Erlotinib Grave
- Darunavir + Erlotinib Grave
- Enzalutamide + Erlotinib Grave
Perguntas frequentes
Can I take Dexlansoprazole with Erlotinib?
MediHelp rates the interaction as major. Dexlansoprazole and Erlotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dexlansoprazole raises gastric pH, which lowers the solubility and absorption of erlotinib. Reduced exposure may impair antitumour efficacy.
How serious is the interaction between Dexlansoprazole and Erlotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid proton pump inhibitors if possible; if acid suppression is needed, use an H2 antagonist separated from erlotinib (erlotinib 2 hours before or 10 hours after) or an antacid separated by hours.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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