Interações medicamentosas
Ethinyl estradiol-levonorgestrel + Fezolinetant
Gravidade: Contraindicada
Ethinyl estradiol-levonorgestrel and Fezolinetant: contraindicated interaction.
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Resumo
Fezolinetant is metabolized mainly by CYP1A2, and ethinyl estradiol is a weak CYP1A2 inhibitor that can raise fezolinetant exposure. Fezolinetant labeling contraindicates use with CYP1A2 inhibitors, and its indication for menopausal vasomotor symptoms means combined contraceptive use is rarely appropriate anyway. Increased exposure raises the risk of hepatotoxicity.
O que esta interação significa em palavras simples
Ethinyl estradiol-levonorgestrel and Fezolinetant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Fezolinetant belongs to Endocrine.
Por que acontece
Ethinyl estradiol inhibits CYP1A2, reducing fezolinetant metabolism and increasing its plasma concentration.
O que fazer
Avoid coadministration. Use an alternative approach for vasomotor symptoms or contraception, and monitor liver tests if fezolinetant is used.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicada
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicada
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Grave
- Amobarbital + Ethinyl estradiol-levonorgestrel Grave
- Anastrozole + Ethinyl estradiol-levonorgestrel Grave
- Antithrombin alfa + Ethinyl estradiol-levonorgestrel Grave
Outras interações de Fezolinetant
- Cimetidine + Fezolinetant Contraindicada
- Ciprofloxacin + Fezolinetant Contraindicada
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicada
- Estradiol + Fezolinetant Contraindicada
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicada
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicada
Perguntas frequentes
Can I take Ethinyl estradiol-levonorgestrel with Fezolinetant?
MediHelp rates the interaction as contraindicated. Ethinyl estradiol-levonorgestrel and Fezolinetant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fezolinetant is metabolized mainly by CYP1A2, and ethinyl estradiol is a weak CYP1A2 inhibitor that can raise fezolinetant exposure. Fezolinetant labeling contraindicates use with CYP1A2 inhibitors, and its indication for menopausal vasomotor symptoms means combined contraceptive use is rarely appropriate anyway. Increased exposure raises the risk of hepatotoxicity.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Fezolinetant?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration. Use an alternative approach for vasomotor symptoms or contraception, and monitor liver tests if fezolinetant is used.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid, Aminocaproic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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