Interações medicamentosas
Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Gravidade: Contraindicada
Ethinyl estradiol-levonorgestrel and Ombitasvir / paritaprevir / ritonavir and dasabuvir: contraindicated interaction.
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Resumo
Coadministration of ethinyl estradiol-containing products with this HCV regimen has produced marked ALT elevations in clinical trials. The risk of liver injury makes the combination unsuitable. Ritonavir may also reduce contraceptive hormone exposure.
O que esta interação significa em palavras simples
Ethinyl estradiol-levonorgestrel and Ombitasvir / paritaprevir / ritonavir and dasabuvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
The mechanism of the ALT elevation is not established; ritonavir may also alter estrogen metabolism.
O que fazer
Avoid ethinyl estradiol-containing contraceptives before and during this regimen. Switch to a progestin-only or non-hormonal method and restart estrogen only after the regimen has been completed, as advised in the labeling.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicada
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicada
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Grave
- Amobarbital + Ethinyl estradiol-levonorgestrel Grave
- Anastrozole + Ethinyl estradiol-levonorgestrel Grave
- Antithrombin alfa + Ethinyl estradiol-levonorgestrel Grave
Perguntas frequentes
Can I take Ethinyl estradiol-levonorgestrel with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as contraindicated. Ethinyl estradiol-levonorgestrel and Ombitasvir / paritaprevir / ritonavir and dasabuvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Coadministration of ethinyl estradiol-containing products with this HCV regimen has produced marked ALT elevations in clinical trials. The risk of liver injury makes the combination unsuitable. Ritonavir may also reduce contraceptive hormone exposure.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ethinyl estradiol-containing contraceptives before and during this regimen. Switch to a progestin-only or non-hormonal method and restart estrogen only after the regimen has been completed, as advised in the labeling.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Tranexamic acid, Aminocaproic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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