Interações medicamentosas
Etonogestrel + Lesinurad
Gravidade: Moderada
Etonogestrel and Lesinurad: moderate interaction.
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Resumo
Lesinurad is a weak CYP3A inducer and may lower exposure to hormonal contraceptives metabolized by CYP3A4. This could reduce contraceptive efficacy and risk unintended pregnancy.
O que esta interação significa em palavras simples
Etonogestrel and Lesinurad can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etonogestrel belongs to Endocrine; Lesinurad belongs to Genitourinary.
Por que acontece
Weak induction of CYP3A4 by lesinurad increases metabolism of the progestin.
O que fazer
Advise an additional nonhormonal contraceptive method while lesinurad is used. Note that lesinurad has been discontinued in many markets.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Lesinurad
- Lesinurad + Norethisterone Grave
- Acetylsalicylic acid + Lesinurad Moderada
- Amiodarone + Lesinurad Moderada
- Apalutamide + Lesinurad Moderada
- Desogestrel-ethinyl estradiol + Lesinurad Moderada
- Dienogest / estradiol valerate + Lesinurad Moderada
Outras interações de Etonogestrel
Perguntas frequentes
Can I take Etonogestrel with Lesinurad?
MediHelp rates the interaction as moderate. Etonogestrel and Lesinurad can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lesinurad is a weak CYP3A inducer and may lower exposure to hormonal contraceptives metabolized by CYP3A4. This could reduce contraceptive efficacy and risk unintended pregnancy.
How serious is the interaction between Etonogestrel and Lesinurad?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional nonhormonal contraceptive method while lesinurad is used. Note that lesinurad has been discontinued in many markets.
What other medicines interact with Lesinurad?
MediHelp also lists interactions of Lesinurad with, for example, Norethisterone, Acetylsalicylic acid, Amiodarone. The full list is on the Lesinurad page.
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