Interações medicamentosas
Fingolimod + Ponesimod
Gravidade: Contraindicada
Fingolimod and Ponesimod: contraindicated interaction.
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Resumo
Both are sphingosine-1-phosphate receptor modulators that lower heart rate and reduce circulating lymphocytes. Using them together duplicates therapy and increases the risk of bradyarrhythmia, conduction delay and infection.
O que esta interação significa em palavras simples
Fingolimod and Ponesimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fingolimod belongs to Central Nervous System; Ponesimod belongs to Central Nervous System.
Por que acontece
Duplicate S1P receptor modulation producing additive negative chronotropic and immunosuppressive effects.
O que fazer
Do not combine; allow adequate washout of one agent, guided by labeling, before starting the other, with cardiac monitoring at initiation.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicada
- Bcg vaccine live + Fingolimod Contraindicada
- Fingolimod + Pimozide Contraindicada
- Fingolimod + Quinidine Contraindicada
- Fingolimod + Siponimod Contraindicada
- Fingolimod + Sotalol Contraindicada
Outras interações de Ponesimod
- Ponesimod + Siponimod Contraindicada
- Amiodarone + Ponesimod Grave
- Amisulpride + Ponesimod Grave
- Anagrelide + Ponesimod Grave
- Anti-thymocyte + Ponesimod Grave
- Asenapine + Ponesimod Grave
Perguntas frequentes
Can I take Fingolimod with Ponesimod?
MediHelp rates the interaction as contraindicated. Fingolimod and Ponesimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are sphingosine-1-phosphate receptor modulators that lower heart rate and reduce circulating lymphocytes. Using them together duplicates therapy and increases the risk of bradyarrhythmia, conduction delay and infection.
How serious is the interaction between Fingolimod and Ponesimod?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow adequate washout of one agent, guided by labeling, before starting the other, with cardiac monitoring at initiation.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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