Interações medicamentosas
Ponesimod + Siponimod
Gravidade: Contraindicada
Ponesimod and Siponimod: contraindicated interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Both are sphingosine-1-phosphate receptor modulators with the same class effects, including heart rate reduction and immunosuppression. Using them together adds no established benefit and increases the risk of bradyarrhythmia and infection.
O que esta interação significa em palavras simples
Ponesimod and Siponimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ponesimod belongs to Central Nervous System; Siponimod belongs to Central Nervous System.
Por que acontece
Duplicate S1P receptor modulation produces additive effects on heart rate, AV conduction and lymphocyte reduction.
O que fazer
Do not combine these drugs. When switching between them, stop one and allow for its washout and lymphocyte recovery before starting the other, as advised in labeling.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Ponesimod e Siponimod, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Siponimod
- Cladribine + Siponimod Contraindicada
- Fingolimod + Siponimod Contraindicada
- Fluconazole + Siponimod Contraindicada
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicada
- Siponimod + Thioridazine Contraindicada
- Adenovirus types 4 and 7 live + Siponimod Grave
Outras interações de Ponesimod
- Fingolimod + Ponesimod Contraindicada
- Amiodarone + Ponesimod Grave
- Amisulpride + Ponesimod Grave
- Anagrelide + Ponesimod Grave
- Anti-thymocyte + Ponesimod Grave
- Asenapine + Ponesimod Grave
Perguntas frequentes
Can I take Ponesimod with Siponimod?
MediHelp rates the interaction as contraindicated. Ponesimod and Siponimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are sphingosine-1-phosphate receptor modulators with the same class effects, including heart rate reduction and immunosuppression. Using them together adds no established benefit and increases the risk of bradyarrhythmia and infection.
How serious is the interaction between Ponesimod and Siponimod?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine these drugs. When switching between them, stop one and allow for its washout and lymphocyte recovery before starting the other, as advised in labeling.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
