Interações medicamentosas
Fluconazole + Ospemifene
Gravidade: Grave
Fluconazole and Ospemifene: major interaction.
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Resumo
Fluconazole inhibits several enzymes involved in ospemifene clearance and increases its exposure. Labeling advises avoiding fluconazole, which is a dual CYP3A4 and CYP2C9 inhibitor, because of the higher exposure and the risk of adverse effects including thromboembolic events and endometrial effects.
O que esta interação significa em palavras simples
Fluconazole and Ospemifene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Ospemifene belongs to Endocrine.
Por que acontece
Fluconazole inhibits CYP3A4, CYP2C9 and CYP2C19, which metabolize ospemifene.
O que fazer
Avoid concomitant use with fluconazole where possible. If an antifungal is needed, use a short course of an agent that does not inhibit these enzymes or withhold ospemifene.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicada
- Dihydroergotamine + Fluconazole Contraindicada
- Dofetilide + Fluconazole Contraindicada
- Dronedarone + Fluconazole Contraindicada
- Erythromycin + Fluconazole Contraindicada
- Flibanserin + Fluconazole Contraindicada
Outras interações de Ospemifene
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicada
- Estradiol + Ospemifene Contraindicada
- Clomiphene + Ospemifene Grave
- Ketoconazole + Ospemifene Grave
- Ospemifene + Raloxifene Grave
- Ospemifene + Rifampicin Grave
Perguntas frequentes
Can I take Fluconazole with Ospemifene?
MediHelp rates the interaction as major. Fluconazole and Ospemifene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole inhibits several enzymes involved in ospemifene clearance and increases its exposure. Labeling advises avoiding fluconazole, which is a dual CYP3A4 and CYP2C9 inhibitor, because of the higher exposure and the risk of adverse effects including thromboembolic events and endometrial effects.
How serious is the interaction between Fluconazole and Ospemifene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use with fluconazole where possible. If an antifungal is needed, use a short course of an agent that does not inhibit these enzymes or withhold ospemifene.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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