Interações medicamentosas
Dofetilide + Fluconazole
Gravidade: Contraindicada
Dofetilide and Fluconazole: contraindicated interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Both drugs prolong the QT interval, and fluconazole may also reduce dofetilide elimination, raising its levels. This markedly increases the risk of torsades de pointes and fatal ventricular arrhythmia.
O que esta interação significa em palavras simples
Dofetilide and Fluconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dofetilide belongs to Cardiovascular; Fluconazole belongs to Anti Fungals.
Por que acontece
Additive QT prolongation, with possible fluconazole-related increase in dofetilide exposure via CYP3A4 and renal transport inhibition.
O que fazer
Avoid the combination; use a non-QT-prolonging antifungal. If systemic azole therapy is essential, consider an alternative antiarrhythmic.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Dofetilide e Fluconazole, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicada
- Dihydroergotamine + Fluconazole Contraindicada
- Dronedarone + Fluconazole Contraindicada
- Erythromycin + Fluconazole Contraindicada
- Flibanserin + Fluconazole Contraindicada
- Fluconazole + Levoketoconazole Contraindicada
Outras interações de Dofetilide
- Amiodarone + Dofetilide Contraindicada
- Amisulpride + Dofetilide Contraindicada
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicada
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicada
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicada
- Captopril-hydrochlorothiazide + Dofetilide Contraindicada
Perguntas frequentes
Can I take Dofetilide with Fluconazole?
MediHelp rates the interaction as contraindicated. Dofetilide and Fluconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and fluconazole may also reduce dofetilide elimination, raising its levels. This markedly increases the risk of torsades de pointes and fatal ventricular arrhythmia.
How serious is the interaction between Dofetilide and Fluconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use a non-QT-prolonging antifungal. If systemic azole therapy is essential, consider an alternative antiarrhythmic.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dronedarone. The full list is on the Fluconazole page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
