Interações medicamentosas
Fluvoxamine + Mexiletine
Gravidade: Grave
Fluvoxamine and Mexiletine: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Mexiletine is metabolized partly by CYP1A2 and CYP2D6, and fluvoxamine strongly inhibits CYP1A2, so mexiletine exposure can increase. This raises the risk of neurologic and gastrointestinal adverse effects and proarrhythmia.
O que esta interação significa em palavras simples
Fluvoxamine and Mexiletine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluvoxamine belongs to Central Nervous System; Mexiletine belongs to Cardiovascular.
Por que acontece
Fluvoxamine inhibits CYP1A2 (and to a lesser extent other enzymes), reducing mexiletine clearance.
O que fazer
Reduce the mexiletine dose and monitor for toxicity and ECG changes, or choose an alternative antidepressant that does not inhibit CYP1A2.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Fluvoxamine e Mexiletine, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Outras interações de Mexiletine
- Fezolinetant + Mexiletine Contraindicada
- Mexiletine + Pimozide Contraindicada
- Alosetron + Mexiletine Grave
- Amiodarone + Mexiletine Grave
- Clozapine + Mexiletine Grave
- Cobicistat + Mexiletine Grave
Outras interações de Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicada
- Alosetron + Fluvoxamine Contraindicada
- Fezolinetant + Fluvoxamine Contraindicada
- Fluvoxamine + Isocarboxazid Contraindicada
- Fluvoxamine + Mavacamten Contraindicada
- Fluvoxamine + Methylene blue Contraindicada
Perguntas frequentes
Can I take Fluvoxamine with Mexiletine?
MediHelp rates the interaction as major. Fluvoxamine and Mexiletine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mexiletine is metabolized partly by CYP1A2 and CYP2D6, and fluvoxamine strongly inhibits CYP1A2, so mexiletine exposure can increase. This raises the risk of neurologic and gastrointestinal adverse effects and proarrhythmia.
How serious is the interaction between Fluvoxamine and Mexiletine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the mexiletine dose and monitor for toxicity and ECG changes, or choose an alternative antidepressant that does not inhibit CYP1A2.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
