Interações medicamentosas
Gemifloxacin + Pimozide
Gravidade: Contraindicada
Gemifloxacin and Pimozide: contraindicated interaction.
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Resumo
Gemifloxacin is a fluoroquinolone that can modestly prolong the QTc, and pimozide has a pronounced dose-related QTc-prolonging effect. Using them together adds to delayed repolarisation and raises the risk of torsades de pointes, especially with hypokalaemia, hypomagnesaemia, bradycardia or structural heart disease.
O que esta interação significa em palavras simples
Gemifloxacin and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Gemifloxacin belongs to Anti Bacterial; Pimozide belongs to Central Nervous System.
Por que acontece
Additive blockade of cardiac repolarising potassium currents (hERG)
O que fazer
Do not co-prescribe; choose an agent without QT liability. If one drug cannot be stopped, correct electrolytes and monitor the ECG closely.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicada
- Dofetilide + Gemifloxacin Contraindicada
- Gemifloxacin + Ibutilide Contraindicada
- Gemifloxacin + Thioridazine Contraindicada
- Gemifloxacin + Vandetanib Contraindicada
- Gemifloxacin + Ziprasidone Contraindicada
Outras interações de Pimozide
- Adagrasib + Pimozide Contraindicada
- Amiodarone + Pimozide Contraindicada
- Amisulpride + Pimozide Contraindicada
- Amitriptyline + Pimozide Contraindicada
- Amoxapine + Pimozide Contraindicada
- Anagrelide + Pimozide Contraindicada
Perguntas frequentes
Can I take Gemifloxacin with Pimozide?
MediHelp rates the interaction as contraindicated. Gemifloxacin and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Gemifloxacin is a fluoroquinolone that can modestly prolong the QTc, and pimozide has a pronounced dose-related QTc-prolonging effect. Using them together adds to delayed repolarisation and raises the risk of torsades de pointes, especially with hypokalaemia, hypomagnesaemia, bradycardia or structural heart disease.
How serious is the interaction between Gemifloxacin and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-prescribe; choose an agent without QT liability. If one drug cannot be stopped, correct electrolytes and monitor the ECG closely.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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