Interações medicamentosas
Gemifloxacin + Thioridazine
Gravidade: Contraindicada
Gemifloxacin and Thioridazine: contraindicated interaction.
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Resumo
Gemifloxacin is a fluoroquinolone that can modestly prolong the QTc, and thioridazine has one of the strongest QTc effects among the antipsychotics. Using them together adds to delayed repolarisation and raises the risk of torsades de pointes, especially with hypokalaemia, hypomagnesaemia, bradycardia or structural heart disease.
O que esta interação significa em palavras simples
Gemifloxacin and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Gemifloxacin belongs to Anti Bacterial; Thioridazine belongs to Central Nervous System.
Por que acontece
Additive blockade of cardiac repolarising potassium currents (hERG)
O que fazer
Do not co-prescribe; choose an agent without QT liability. If one drug cannot be stopped, correct electrolytes and monitor the ECG closely.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicada
- Dofetilide + Gemifloxacin Contraindicada
- Gemifloxacin + Ibutilide Contraindicada
- Gemifloxacin + Pimozide Contraindicada
- Gemifloxacin + Vandetanib Contraindicada
- Gemifloxacin + Ziprasidone Contraindicada
Outras interações de Thioridazine
- Abiraterone + Thioridazine Contraindicada
- Adagrasib + Thioridazine Contraindicada
- Amiodarone + Thioridazine Contraindicada
- Amisulpride + Thioridazine Contraindicada
- Amitriptyline + Thioridazine Contraindicada
- Amoxapine + Thioridazine Contraindicada
Perguntas frequentes
Can I take Gemifloxacin with Thioridazine?
MediHelp rates the interaction as contraindicated. Gemifloxacin and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Gemifloxacin is a fluoroquinolone that can modestly prolong the QTc, and thioridazine has one of the strongest QTc effects among the antipsychotics. Using them together adds to delayed repolarisation and raises the risk of torsades de pointes, especially with hypokalaemia, hypomagnesaemia, bradycardia or structural heart disease.
How serious is the interaction between Gemifloxacin and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-prescribe; choose an agent without QT liability. If one drug cannot be stopped, correct electrolytes and monitor the ECG closely.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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