Interações medicamentosas
Glyburide + Oteseconazole
Gravidade: Moderada
Glyburide and Oteseconazole: moderate interaction.
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Resumo
Oteseconazole inhibits BCRP, a transporter involved in glyburide disposition, so glyburide concentrations may rise. This could increase the glucose-lowering effect and the risk of hypoglycemia. Oteseconazole has a very long half-life, so the effect may persist after the course ends.
O que esta interação significa em palavras simples
Glyburide and Oteseconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Oteseconazole belongs to Anti Fungals.
Por que acontece
Oteseconazole inhibits BCRP, reducing efflux of glyburide.
O que fazer
Monitor blood glucose closely during and for some weeks after oteseconazole therapy. Reduce the glyburide dose if low glucose readings occur.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Glyburide
- Bosentan + Glyburide Contraindicada
- Cholic acid + Glyburide Grave
- Ciprofloxacin + Glyburide Grave
- Clarithromycin + Glyburide Grave
- Fluconazole + Glyburide Grave
- Glyburide + Insulin degludec-liraglutide Grave
Outras interações de Oteseconazole
- Atorvastatin + Oteseconazole Moderada
- Fluvastatin + Oteseconazole Moderada
- Glyburide-metformin + Oteseconazole Moderada
- Irinotecan + Oteseconazole Moderada
- Lapatinib + Oteseconazole Moderada
- Leflunomide + Oteseconazole Moderada
Perguntas frequentes
Can I take Glyburide with Oteseconazole?
MediHelp rates the interaction as moderate. Glyburide and Oteseconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oteseconazole inhibits BCRP, a transporter involved in glyburide disposition, so glyburide concentrations may rise. This could increase the glucose-lowering effect and the risk of hypoglycemia. Oteseconazole has a very long half-life, so the effect may persist after the course ends.
How serious is the interaction between Glyburide and Oteseconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during and for some weeks after oteseconazole therapy. Reduce the glyburide dose if low glucose readings occur.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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