Interações medicamentosas
Irinotecan + Oteseconazole
Gravidade: Moderada
Irinotecan and Oteseconazole: moderate interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Oteseconazole inhibits BCRP and may raise exposure to irinotecan and SN-38. This could increase diarrhea and myelosuppression. Oteseconazole is generally used in patients who cannot become pregnant, so co-use is uncommon.
O que esta interação significa em palavras simples
Irinotecan and Oteseconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Irinotecan belongs to Oncology; Oteseconazole belongs to Anti Fungals.
Por que acontece
Oteseconazole inhibits BCRP efflux transport, which may reduce SN-38 elimination.
O que fazer
If both are needed, monitor blood counts and diarrhea closely and consider an irinotecan dose reduction.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Irinotecan e Oteseconazole, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Outras interações de Irinotecan
- Clozapine + Irinotecan Contraindicada
- Irinotecan + Sacituzumab govitecan Contraindicada
- Adenovirus types 4 and 7 live + Irinotecan Grave
- Apalutamide + Irinotecan Grave
- Atazanavir + Irinotecan Grave
- Carbamazepine + Irinotecan Grave
Outras interações de Oteseconazole
- Atorvastatin + Oteseconazole Moderada
- Fluvastatin + Oteseconazole Moderada
- Glyburide-metformin + Oteseconazole Moderada
- Glyburide + Oteseconazole Moderada
- Lapatinib + Oteseconazole Moderada
- Leflunomide + Oteseconazole Moderada
Perguntas frequentes
Can I take Irinotecan with Oteseconazole?
MediHelp rates the interaction as moderate. Irinotecan and Oteseconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oteseconazole inhibits BCRP and may raise exposure to irinotecan and SN-38. This could increase diarrhea and myelosuppression. Oteseconazole is generally used in patients who cannot become pregnant, so co-use is uncommon.
How serious is the interaction between Irinotecan and Oteseconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If both are needed, monitor blood counts and diarrhea closely and consider an irinotecan dose reduction.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
