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Interações medicamentosas

Haloperidol + Sodium phenylbutyrate

Gravidade: Moderada

Haloperidol and Sodium phenylbutyrate: moderate interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

O conteúdo clínico desta página está disponível apenas em inglês.

Resumo

Haloperidol has been reported to raise ammonia in patients with urea cycle disorders, which may undermine phenylbutyrate treatment.

O que esta interação significa em palavras simples

Haloperidol and Sodium phenylbutyrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Haloperidol belongs to Central Nervous System; Sodium phenylbutyrate belongs to Miscellaneous.

Nível de evidência: Low

Por que acontece

The mechanism of haloperidol-related hyperammonemia is not well established.

O que fazer

Monitor plasma ammonia closely if haloperidol is required. Consider alternatives where possible.

O que perguntar ao farmacêutico

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Perguntas frequentes

Can I take Haloperidol with Sodium phenylbutyrate?

MediHelp rates the interaction as moderate. Haloperidol and Sodium phenylbutyrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol has been reported to raise ammonia in patients with urea cycle disorders, which may undermine phenylbutyrate treatment.

How serious is the interaction between Haloperidol and Sodium phenylbutyrate?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor plasma ammonia closely if haloperidol is required. Consider alternatives where possible.

What other medicines interact with Sodium phenylbutyrate?

MediHelp also lists interactions of Sodium phenylbutyrate with, for example, Sodium valproate, Probenecid. The full list is on the Sodium phenylbutyrate page.

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