Interações medicamentosas
Probenecid + Sodium phenylbutyrate
Gravidade: Moderada
Probenecid and Sodium phenylbutyrate: moderate interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Probenecid reduces renal excretion of phenylbutyrate metabolites, including phenylacetate and phenylacetylglutamine. Accumulation may increase adverse effects such as neurotoxicity and affect ammonia control.
O que esta interação significa em palavras simples
Probenecid and Sodium phenylbutyrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Probenecid belongs to Genitourinary; Sodium phenylbutyrate belongs to Miscellaneous.
Por que acontece
Probenecid inhibits renal tubular secretion of phenylbutyrate and its conjugated metabolites via organic anion transporters.
O que fazer
Monitor plasma ammonia and for neurological adverse effects; adjust the phenylbutyrate dose if signs of toxicity appear.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Probenecid e Sodium phenylbutyrate, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Outras interações de Probenecid
- Ketorolac intranasal + Probenecid Contraindicada
- Ketorolac + Probenecid Contraindicada
- Baricitinib + Probenecid Grave
- Ceftazidime / avibactam + Probenecid Grave
- Methotrexate + Probenecid Grave
- Pralatrexate + Probenecid Grave
Outras interações de Sodium phenylbutyrate
Perguntas frequentes
Can I take Probenecid with Sodium phenylbutyrate?
MediHelp rates the interaction as moderate. Probenecid and Sodium phenylbutyrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid reduces renal excretion of phenylbutyrate metabolites, including phenylacetate and phenylacetylglutamine. Accumulation may increase adverse effects such as neurotoxicity and affect ammonia control.
How serious is the interaction between Probenecid and Sodium phenylbutyrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor plasma ammonia and for neurological adverse effects; adjust the phenylbutyrate dose if signs of toxicity appear.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
