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Interações medicamentosas

Heparin + Oritavancin

Gravidade: Contraindicada

Heparin and Oritavancin: contraindicated interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

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Resumo

Oritavancin artificially prolongs aPTT for many days, so unfractionated heparin monitoring becomes unreliable. This may lead to inappropriate dosing and bleeding or thrombosis.

O que esta interação significa em palavras simples

Heparin and Oritavancin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Heparin belongs to Cardiovascular; Oritavancin belongs to Anti Bacterial.

Nível de evidência: High

Por que acontece

Oritavancin binds phospholipid reagents used in coagulation assays, causing laboratory interference rather than a true pharmacodynamic effect.

O que fazer

Avoid IV unfractionated heparin for the period stated in labeling after oritavancin. Use an alternative anticoagulant monitored by a non-aPTT method if needed.

O que perguntar ao farmacêutico

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

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Perguntas frequentes

Can I take Heparin with Oritavancin?

MediHelp rates the interaction as contraindicated. Heparin and Oritavancin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oritavancin artificially prolongs aPTT for many days, so unfractionated heparin monitoring becomes unreliable. This may lead to inappropriate dosing and bleeding or thrombosis.

How serious is the interaction between Heparin and Oritavancin?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid IV unfractionated heparin for the period stated in labeling after oritavancin. Use an alternative anticoagulant monitored by a non-aPTT method if needed.

What other medicines interact with Oritavancin?

MediHelp also lists interactions of Oritavancin with, for example, Warfarin, Carbamazepine, Cyclosporin. The full list is on the Oritavancin page.

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