Interações medicamentosas
Hydromorphone + Olanzapine / samidorphan
Gravidade: Contraindicada
Hydromorphone and Olanzapine / samidorphan: contraindicated interaction.
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Resumo
Samidorphan is an opioid antagonist that blocks hydromorphone's effect and can precipitate acute withdrawal in opioid-dependent patients. Pain control may be lost.
O que esta interação significa em palavras simples
Hydromorphone and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Pharmacodynamic antagonism at opioid receptors by samidorphan.
O que fazer
Do not start in patients using opioids; ensure an opioid-free interval of at least 7 days for short-acting opioids before starting. Choose another antipsychotic if opioid therapy is needed.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Hydromorphone
- Alvimopan + Hydromorphone Contraindicada
- Bupropion-naltrexone + Hydromorphone Contraindicada
- Hydromorphone + Isocarboxazid Contraindicada
- Hydromorphone + Phenelzine Contraindicada
- Hydromorphone + Tranylcypromine Contraindicada
- Alfentanil + Hydromorphone Grave
Perguntas frequentes
Can I take Hydromorphone with Olanzapine / samidorphan?
MediHelp rates the interaction as contraindicated. Hydromorphone and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Samidorphan is an opioid antagonist that blocks hydromorphone's effect and can precipitate acute withdrawal in opioid-dependent patients. Pain control may be lost.
How serious is the interaction between Hydromorphone and Olanzapine / samidorphan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not start in patients using opioids; ensure an opioid-free interval of at least 7 days for short-acting opioids before starting. Choose another antipsychotic if opioid therapy is needed.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
Monografias completas, posologia e verificador de interações no app MediHelp
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