Interações medicamentosas
Hydromorphone + Tranylcypromine
Gravidade: Contraindicada
Hydromorphone and Tranylcypromine: contraindicated interaction.
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Resumo
Opioids given with nonselective MAOIs have caused severe reactions including hypotension, hyperthermia, respiratory depression and coma. Hydromorphone labeling advises against use during or within 14 days of MAOI therapy.
O que esta interação significa em palavras simples
Hydromorphone and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Hydromorphone belongs to Musculoskeletal; Tranylcypromine belongs to Central Nervous System.
Por que acontece
Irreversible MAO inhibition may potentiate opioid CNS and respiratory depression and cause serotonergic or autonomic instability; the exact mechanism is not fully defined.
O que fazer
Do not combine and wait at least 14 days after stopping tranylcypromine before starting hydromorphone. Use an alternative analgesic if an MAOI is required.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Hydromorphone
- Alvimopan + Hydromorphone Contraindicada
- Bupropion-naltrexone + Hydromorphone Contraindicada
- Hydromorphone + Isocarboxazid Contraindicada
- Hydromorphone + Olanzapine / samidorphan Contraindicada
- Hydromorphone + Phenelzine Contraindicada
- Alfentanil + Hydromorphone Grave
Outras interações de Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicada
- Amitriptyline + Tranylcypromine Contraindicada
- Amoxapine + Tranylcypromine Contraindicada
- Atomoxetine + Tranylcypromine Contraindicada
- Benzphetamine + Tranylcypromine Contraindicada
- Brimonidine + Tranylcypromine Contraindicada
Perguntas frequentes
Can I take Hydromorphone with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Hydromorphone and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Opioids given with nonselective MAOIs have caused severe reactions including hypotension, hyperthermia, respiratory depression and coma. Hydromorphone labeling advises against use during or within 14 days of MAOI therapy.
How serious is the interaction between Hydromorphone and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine and wait at least 14 days after stopping tranylcypromine before starting hydromorphone. Use an alternative analgesic if an MAOI is required.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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