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Interações medicamentosas

Ifosfamide + Rotavirus oral vaccine live

Gravidade: Contraindicada

Ifosfamide and Rotavirus oral vaccine live: contraindicated interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

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Resumo

Rotavirus vaccine contains live attenuated virus, which could replicate excessively in a patient immunosuppressed by ifosfamide. This raises the risk of prolonged vaccine-virus gastrointestinal infection, and the vaccine response may be reduced.

O que esta interação significa em palavras simples

Ifosfamide and Rotavirus oral vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Nível de evidência: Moderate

Por que acontece

Chemotherapy-induced immunosuppression allows unchecked replication of live attenuated virus and impairs the vaccine response.

O que fazer

Avoid live vaccines during ifosfamide therapy and for at least 3 months after it ends. Seek specialist advice if an infant is exposed through a treated household member.

O que perguntar ao farmacêutico

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

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Perguntas frequentes

Can I take Ifosfamide with Rotavirus oral vaccine live?

MediHelp rates the interaction as contraindicated. Ifosfamide and Rotavirus oral vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rotavirus vaccine contains live attenuated virus, which could replicate excessively in a patient immunosuppressed by ifosfamide. This raises the risk of prolonged vaccine-virus gastrointestinal infection, and the vaccine response may be reduced.

How serious is the interaction between Ifosfamide and Rotavirus oral vaccine live?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during ifosfamide therapy and for at least 3 months after it ends. Seek specialist advice if an infant is exposed through a treated household member.

What other medicines interact with Ifosfamide?

MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.

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