Interações medicamentosas
Imatinib + Ponatinib
Gravidade: Grave
Imatinib and Ponatinib: major interaction.
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Resumo
Imatinib may increase ponatinib exposure, which carries risks of arterial occlusion, heart failure, hepatotoxicity and pancreatitis. Both are BCR-ABL inhibitors, so the combination is rarely rational.
O que esta interação significa em palavras simples
Imatinib and Ponatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Imatinib belongs to Oncology; Ponatinib belongs to Oncology.
Por que acontece
Imatinib inhibits CYP3A4, a main route of ponatinib metabolism, and both drugs have overlapping toxicities.
O que fazer
Avoid combining the two. If coadministration is unavoidable, monitor for vascular events, liver function and pancreatitis and consider a reduced ponatinib dose.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Imatinib
- Imatinib + Lomitapide Contraindicada
- Imatinib + Lonafarnib Contraindicada
- Amobarbital + Imatinib Grave
- Apalutamide + Imatinib Grave
- Avapritinib + Imatinib Grave
- Benzhydrocodone / acetaminophen + Imatinib Grave
Outras interações de Ponatinib
Perguntas frequentes
Can I take Imatinib with Ponatinib?
MediHelp rates the interaction as major. Imatinib and Ponatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Imatinib may increase ponatinib exposure, which carries risks of arterial occlusion, heart failure, hepatotoxicity and pancreatitis. Both are BCR-ABL inhibitors, so the combination is rarely rational.
How serious is the interaction between Imatinib and Ponatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining the two. If coadministration is unavoidable, monitor for vascular events, liver function and pancreatitis and consider a reduced ponatinib dose.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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