Interações medicamentosas
Indomethacin + Ketorolac intranasal
Gravidade: Contraindicada
Indomethacin and Ketorolac intranasal: contraindicated interaction.
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Ketorolac is contraindicated with other NSAIDs because the combination increases the risk of gastrointestinal bleeding, perforation and renal impairment. Intranasal ketorolac is systemically absorbed, so the warning applies.
O que esta interação significa em palavras simples
Indomethacin and Ketorolac intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Additive cyclooxygenase inhibition causing GI mucosal injury, platelet inhibition and reduced renal prostaglandins.
O que fazer
Do not use together. Use one NSAID at a time and choose a non-NSAID analgesic such as paracetamol if more analgesia is needed.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Referências
Outras interações de Indomethacin
- Indomethacin + Ketorolac Contraindicada
- Aceclofenac + Indomethacin Grave
- Acemetacin + Indomethacin Grave
- Acetylsalicylic acid + Indomethacin Grave
- Alteplase + Indomethacin Grave
- Amiloride + Indomethacin Grave
Perguntas frequentes
Can I take Indomethacin with Ketorolac intranasal?
MediHelp rates the interaction as contraindicated. Indomethacin and Ketorolac intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketorolac is contraindicated with other NSAIDs because the combination increases the risk of gastrointestinal bleeding, perforation and renal impairment. Intranasal ketorolac is systemically absorbed, so the warning applies.
How serious is the interaction between Indomethacin and Ketorolac intranasal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Use one NSAID at a time and choose a non-NSAID analgesic such as paracetamol if more analgesia is needed.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Aceclofenac, Acemetacin. The full list is on the Indomethacin page.
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