Interações medicamentosas
Amiloride + Indomethacin
Gravidade: Grave
Amiloride and Indomethacin: major interaction.
Última atualização Fontes: US FDA label
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Resumo
Indomethacin can blunt renal potassium excretion while amiloride is potassium-sparing, so combined use can cause hyperkalemia. NSAIDs may also reduce the diuretic and antihypertensive effect of amiloride and worsen renal function.
O que esta interação significa em palavras simples
Amiloride and Indomethacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiloride belongs to Cardiovascular; Indomethacin belongs to Musculoskeletal.
Por que acontece
Additive potassium retention: amiloride blocks ENaC and indomethacin suppresses prostaglandin-mediated renin and aldosterone and renal potassium excretion.
O que fazer
Avoid the combination where possible; if used, monitor serum potassium and creatinine within the first week and periodically after, especially in the elderly, diabetics or those with renal impairment.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Indomethacin
- Indomethacin + Ketorolac Contraindicada
- Indomethacin + Ketorolac intranasal Contraindicada
- Aceclofenac + Indomethacin Grave
- Acemetacin + Indomethacin Grave
- Acetylsalicylic acid + Indomethacin Grave
- Alteplase + Indomethacin Grave
Outras interações de Amiloride
- Amiloride + Eplerenone Contraindicada
- Amiloride + Spironolactone Contraindicada
- Amiloride + Triamterene Contraindicada
- Aceclofenac + Amiloride Grave
- Acemetacin + Amiloride Grave
- Amiloride + Amlodipine-benazepril Grave
Perguntas frequentes
Can I take Amiloride with Indomethacin?
MediHelp rates the interaction as major. Amiloride and Indomethacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indomethacin can blunt renal potassium excretion while amiloride is potassium-sparing, so combined use can cause hyperkalemia. NSAIDs may also reduce the diuretic and antihypertensive effect of amiloride and worsen renal function.
How serious is the interaction between Amiloride and Indomethacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor serum potassium and creatinine within the first week and periodically after, especially in the elderly, diabetics or those with renal impairment.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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