Interações medicamentosas
Levothyroxine + Sodium iodide i-131
Gravidade: Grave
Levothyroxine and Sodium iodide i-131: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Exogenous thyroid hormone suppresses TSH and reduces thyroid tissue iodine uptake, so less radioiodine reaches the thyroid or thyroid cancer remnants. This can make diagnostic uptake studies unreliable and reduce the therapeutic effect of I-131.
O que esta interação significa em palavras simples
Levothyroxine and Sodium iodide i-131 can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Levothyroxine suppresses TSH-driven iodide uptake by thyroid tissue, lowering I-131 accumulation.
O que fazer
Withhold levothyroxine for the period specified in the radioiodine protocol (or use recombinant TSH stimulation) before I-131 dosing. Restart thyroid hormone after treatment as directed by the nuclear medicine or endocrine team.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Levothyroxine e Sodium iodide i-131, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Levothyroxine
- Cholestyramine + Levothyroxine Grave
- Levothyroxine + Tiratricol Grave
- Adrenaline-articaine + Levothyroxine Moderada
- Alogliptin-metformin + Levothyroxine Moderada
- Amitriptyline + Levothyroxine Moderada
- Amobarbital + Levothyroxine Moderada
Perguntas frequentes
Can I take Levothyroxine with Sodium iodide i-131?
MediHelp rates the interaction as major. Levothyroxine and Sodium iodide i-131 can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Exogenous thyroid hormone suppresses TSH and reduces thyroid tissue iodine uptake, so less radioiodine reaches the thyroid or thyroid cancer remnants. This can make diagnostic uptake studies unreliable and reduce the therapeutic effect of I-131.
How serious is the interaction between Levothyroxine and Sodium iodide i-131?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Withhold levothyroxine for the period specified in the radioiodine protocol (or use recombinant TSH stimulation) before I-131 dosing. Restart thyroid hormone after treatment as directed by the nuclear medicine or endocrine team.
What other medicines interact with Levothyroxine?
MediHelp also lists interactions of Levothyroxine with, for example, Cholestyramine, Tiratricol, Adrenaline-articaine. The full list is on the Levothyroxine page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
