Interações medicamentosas
Amitriptyline + Levothyroxine
Gravidade: Moderada
Amitriptyline and Levothyroxine: moderate interaction.
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Resumo
Thyroid hormone may increase sensitivity to the effects of tricyclic antidepressants, and combined use has been associated with tachycardia and arrhythmias. Antidepressant response may also be accelerated, but toxicity may emerge more readily, particularly in patients with excess thyroid hormone.
O que esta interação significa em palavras simples
Amitriptyline and Levothyroxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Levothyroxine belongs to Endocrine.
Por que acontece
Thyroid hormone increases beta-adrenergic receptor sensitivity, adding to tricyclic noradrenergic and cardiac effects.
O que fazer
Monitor heart rate, rhythm and thyroid function, and avoid over-replacement with levothyroxine. Watch for tricyclic toxicity and ECG changes in patients with cardiac disease.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicada
- Amitriptyline + Methylene blue Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amitriptyline + Pimozide Contraindicada
- Amitriptyline + Procarbazine Contraindicada
- Amitriptyline + Safinamide Contraindicada
Outras interações de Levothyroxine
Perguntas frequentes
Can I take Amitriptyline with Levothyroxine?
MediHelp rates the interaction as moderate. Amitriptyline and Levothyroxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormone may increase sensitivity to the effects of tricyclic antidepressants, and combined use has been associated with tachycardia and arrhythmias. Antidepressant response may also be accelerated, but toxicity may emerge more readily, particularly in patients with excess thyroid hormone.
How serious is the interaction between Amitriptyline and Levothyroxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and thyroid function, and avoid over-replacement with levothyroxine. Watch for tricyclic toxicity and ECG changes in patients with cardiac disease.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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