Interações medicamentosas
Lidocaine + Procainamide
Gravidade: Grave
Lidocaine and Procainamide: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Both are class I antiarrhythmics that depress cardiac conduction, so combined use can cause additive effects such as conduction delay, hypotension and proarrhythmia. Additive CNS toxicity, such as confusion or seizures, has also been described with both agents.
O que esta interação significa em palavras simples
Lidocaine and Procainamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive sodium channel blockade slowing cardiac conduction, with overlapping CNS toxicity.
O que fazer
Use together only with continuous ECG and blood pressure monitoring, and avoid unless clearly necessary. Reduce doses and watch for QRS widening, hypotension and neurologic symptoms.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Lidocaine e Procainamide, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Outras interações de Lidocaine
- Bupivacaine liposome + Lidocaine Grave
- Disopyramide + Lidocaine Grave
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Grave
- Lidocaine + Nirmatrelvir / ritonavir Grave
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Grave
- Lidocaine + Pimozide Grave
Perguntas frequentes
Can I take Lidocaine with Procainamide?
MediHelp rates the interaction as major. Lidocaine and Procainamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are class I antiarrhythmics that depress cardiac conduction, so combined use can cause additive effects such as conduction delay, hypotension and proarrhythmia. Additive CNS toxicity, such as confusion or seizures, has also been described with both agents.
How serious is the interaction between Lidocaine and Procainamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only with continuous ECG and blood pressure monitoring, and avoid unless clearly necessary. Reduce doses and watch for QRS widening, hypotension and neurologic symptoms.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
