Interações medicamentosas
Lorlatinib + Pentobarbital
Gravidade: Contraindicada
Lorlatinib and Pentobarbital: contraindicated interaction.
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Resumo
Barbiturates are potent inducers of CYP3A4 and can markedly lower lorlatinib concentrations, risking loss of tumour control. The strong inducer rifampin was also associated with liver enzyme elevations when given with lorlatinib. Labeling contraindicates strong CYP3A inducers.
O que esta interação significa em palavras simples
Lorlatinib and Pentobarbital are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Induction of CYP3A4 accelerates lorlatinib metabolism and lowers exposure.
O que fazer
Do not combine; choose a non-inducing sedative or anticonvulsant. If an inducer was used, stop it for about 3 half-lives before starting lorlatinib.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Lorlatinib
- Amobarbital + Lorlatinib Contraindicada
- Apalutamide + Lorlatinib Contraindicada
- Butabarbital + Lorlatinib Contraindicada
- Carbamazepine + Lorlatinib Contraindicada
- Enzalutamide + Lorlatinib Contraindicada
- Fosphenytoin + Lorlatinib Contraindicada
Perguntas frequentes
Can I take Lorlatinib with Pentobarbital?
MediHelp rates the interaction as contraindicated. Lorlatinib and Pentobarbital are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Barbiturates are potent inducers of CYP3A4 and can markedly lower lorlatinib concentrations, risking loss of tumour control. The strong inducer rifampin was also associated with liver enzyme elevations when given with lorlatinib. Labeling contraindicates strong CYP3A inducers.
How serious is the interaction between Lorlatinib and Pentobarbital?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose a non-inducing sedative or anticonvulsant. If an inducer was used, stop it for about 3 half-lives before starting lorlatinib.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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